Contrarily, the location of the tumor cells, TAFs and TAMs further away from the tumor vasculature accounts for a much slower and persistent accumulation as seen for the Bi-FAP/mEnd-IL, FAP-IL and LipQ, but not the mEnd-IL in the FAP-expressing fibrosarcoma model (HT1080-hFAP) and also for the FAP-IL and LipQ in the breast carcinoma (MDA-MB231) model. The gene discussed is FAP; the disease is fibrosarcoma.