For example, the oncogenic Kaposi’s sarcoma-associated herpesvirus (KSHV), human herpesvirus 8, contained a constitutively active GPCR homolog, which could stimulate the secretion of vascular endothelial growth factor (VEGF), a key angiogenic stimulator and a critical mitogen for the development of Kaposi’s sarcoma [52]. This evidence concerns the gene VEGFA and Kaposi's sarcoma.