In these studies, we observed that MSCs could protect MM-cells from highly lytic BCMA-CAR T-cells only at very low effector to target cell ratios, while they readily inhibited the MM-cell lysis by moderately lytic CD38-specific and CD138-specific CAR T-cells, which were generated using intermediate to low affinity antibodies. The gene discussed is SDC1; the disease is Miyoshi myopathy.