This type of “BM-ME-mediated immune resistance” is also “tumor intrinsic” and is established by the intensive cross-talk of MM-cells with the cells of the BM-ME via soluble factors such as IL-6, APRIL and growth factors, but most importantly via the integrin-mediated cell adhesion and Notch signaling (Figure 1 and Figure 2). The gene discussed is IL6; the disease is Miyoshi myopathy.