Furthermore, the sh-RNA-mediated downregulation of Survivin or inhibition of Survivin and MCL-1 expression with a small inhibitory molecule, YM155, largely abrogated the protective effects of MSCs and synergistically upregulated the lysis of MM-cells by CTLs as well by Daratumumab in ADCC assays [86,87]. Here, BIRC5 is linked to Miyoshi myopathy.