A further recurrently mutated gene in OAML (6% of cases) is DOCK8. The fact that DOCK8 is involved in RhoGTPase signaling, that germline loss of DOCK8 causes an immunodeficiency, that it has an important role in murine B cell differentiation, and that mutations of this gene have previously been reported in other cancers [46,47], point to a potential involvement of DOCK8 mutations in the pathogenesis of OAML. Here, DOCK8 is linked to immunodeficiency disease.