After treatment of breast cancer MDA-MB-231 cells with DOX, we observed several phenomena: (1) cellular senescence; (2) polyploidization by mitotic slippage; (3) activation of meiotic genes; (4) extranuclear sorting of the cut-off circularized telomere ends along with the signs of the telomere maintenance mechanism by ALT in these polyploidized cell nuclei; and (5) amoeboid conversion of these cells with final sporogenesis-like budding of their depolyploidized progeny restarting mitotic cycling. The gene discussed is GPT; the disease is breast cancer.