CB1 inhibition with rimonabant (10 mg/kg/day) in the mice model of nonalcoholic fatty liver disease (NAFLD) improved adipokine profile, decreased glucose plasma concentration, and reduced inflammation in adipose tissues and liver [242] and in the rat model of nonalcoholic steatohepatitis (NASH) inhibited hepatic fat infiltration, inflammation, fibrogenesis, and cellular death [243]. This evidence concerns the gene CNR1 and metabolic dysfunction-associated steatotic liver disease.