The decrease in levels of METTL3 induced apoptosis and slowed tumorigenesis in NSCLC [105] due that METTL3 promotes translation of oncogenic mRNAs including EGFR [165] and bromodomain-containing protein 4 (BRD4) [167] (Figure 1). The gene discussed is BRD4; the disease is non-small cell lung carcinoma.