SPRED1 and non-small cell lung carcinoma: Similarly, overexpression of miR-31 increases tumorigenesis via decreasing RAS p21 protein activator 1 (RASA1), sprouty related EVH1 domain containing 1/2 (SPRED1/2), and Sprouty 1/3/4 (SPRY1/3/4) in KRAS-driven NSCLC [91].