APEX1 and non-small cell lung carcinoma: As for the role of miRNA, it was found that the overexpression of miR-296-3p reduced the level of phosphorylation in this pathway without reducing mRNA expression by targeting apurinic/apyrimidinic endodeoxyribonuclease 1 (APEX1), therefore possibly inhibiting the pathway’s progression particularly in NSCLC [241].