Of interest with identical experimental CRC models, the pharmacologic p38α MAPK inhibition (SB203580) exerts protective effects against 5-FU induced apoptosis, suggesting that, in addition to an MKK3/p38δ MAPK pro-survival signaling, a p38α MAPK pro-apoptotic signaling is triggered by 5-FU and possibly mediated by a different upstream kinase (likely, MKK6) [19]. This evidence concerns the gene MAP2K3 and colorectal carcinoma.