ProFAT analysis of the expression profile of white and brown marker genes revealed that 11 brown marker genes were significantly lower (ACAA2, SLC25A20, ACO2, HADHB, ETFDH, SDHB, NDUFS1, ACADS, DLD, ETFB, PDHA1) and two white markers (ALCAM, HOXC8) were significantly higher expressed in FTO C/C obesity-risk genotype (Figure 6A, red rectangle). The gene discussed is HOXC8; the disease is obesity due to melanocortin 4 receptor deficiency.