Out of these, 624 genes (e.g., CKMT1A/B, CITED1, PPARGC1A/B, and CPT1B) were lower expressed in those adipocytes that carried the obesity-risk genotype and the enriched pathways (maintained by the normal T/T genotype) included fatty acid metabolism, thermogenesis, respiratory electron transport, and the signaling by retinoic acid (which showed DN specific appearance as well). This evidence concerns the gene CPT1B and obesity due to melanocortin 4 receptor deficiency.