Comparing the FTO status-related gene expression patterns to upregulated DEGs in DN versus SC adipocytes, we found that out of the 529 genes (Groups 1 and 2) that were significantly higher in the DN samples, 33 genes were poorly expressed in the FTO obesity-risk genotype samples (Figure 6L and Table S7). Here, FTO is linked to obesity due to melanocortin 4 receptor deficiency.