PDCD1 and cancer: Finally, Su et al. also reported the PD-1 disruption effect of two PD-1 exon 2-targeting sgRNAs (5′-GTGACTTCCACATGAGCGTGG-3′ and 5′-CCGCTTCCGTGTCACACAACTGCC-3′) in cancer-antigen-specific T cells derived from cancer patients [30].