Among various kinds of damage-associated molecular patterns (DAMPs), we focused on HSP72 as it is evoked by stress exposure via SNS activation [25], and was found to increase mRNA expression levels of TNF-α and IL-8 in human BM neutrophils [26], which were elevated in the bronchoalveolar lavage in cystic fibrosis (CF) patients and directly contributed to the enhanced NE release [24]. The gene discussed is TNF; the disease is cystic fibrosis.