Thus, mutations in the human ENDOGLIN gene (ENG) cause Hereditary Hemorrhagic Telangiectasia (HHT) type 1, a dominant vascular disease that present with nose and gastrointestinal bleedings, telangiectases on skin and mucosa, and arteriovenous malformations in lung, liver, and brain [8,9,10]. Here, ENG is linked to hereditary hemorrhagic telangiectasia.