In addition, Th17 responses are involved in IMQ-induced psoriasis-like lesions, and the combination of Acar and low-dose CsA could significantly modulate the serum and skin expression levels of Th17 cytokines (IL-17A, IL-22, and IL-23) compared with Acar alone or low-dose CsA alone. The gene discussed is IL17A; the disease is psoriasis.