NLRX1 and viral infectious disease: NLRX1 is a component of a regulatory mitochondrial protein complex that also comprises the mitochondrial Tu translation elongation factor (TUFM), which, following viral infection, mediates the induction of IFN-I and autophagy through RIG-I and the autophagy-related proteins Atg5-Atg12 conjugate and Atg16L1 [115,116,117].