As cancer cells often form micronuclei or cytoplasmic DNA that may activate cGAS–STING signaling, it has become increasingly clear that the inactivation of this pathway is an efficient strategy for the virus to limit the induction of inflammatory and immune stimulatory molecules with tumor-killing activity (e.g., cytokines and NK ligands) [59,105,106,107,108,109,110,111,112,113]. This evidence concerns the gene STING1 and neoplasm.