As all non-functioning PitNETs (GTs and sCTs) were macroadenomas, while some functioning PitNETs (fCTs and STs) were microadenomas, the effect of E2F1 on the growth and invasiveness of pituitary tumours could be mediated by its interaction with MYC and miR-17-5p. This evidence concerns the gene MYC and pituitary tumor.