As all non-functioning PitNETs (GTs and sCTs) were macroadenomas, while some functioning PitNETs (fCTs and STs) were microadenomas, the effect of E2F1 on the growth and invasiveness of pituitary tumours could be mediated by its interaction with MYC and miR-17-5p. The gene discussed is E2F1; the disease is pituitary tumor.