CCNA2 and neoplasm: Finally, the expressions of miR-23b and miR-130b, which target HMGA2 and CCNA2 genes [41], have been reported as down-regulated in somatotroph, gonadotroph, and silent PitNETs, while miR-183, which targets KIAA0101 [42], appears to be down-regulated in aggressive lactotroph tumours.