The four genes regulated by both PUM1 and PUM2 encode DOCK9, ADAMTS9, GABRQ, and ANKRD1, which are involved in filopodia formation in cervical cancer, cell cycle regulation and ovary cancer progression, promotion of cell proliferation in hepatocellular carcinoma, and downregulation of apoptosis, respectively. This evidence concerns the gene PUM2 and hepatocellular carcinoma.