In the current work, the underlying molecular mechanism of MID1IP1 as a potent oncogene was elucidated in association with c-Myc mediated by ribosomal protein L5 or L11 and CNOT2 in HCCs, with the hypothesis that MID1IP1 with hyperlipidemic activity [19,20] may act as a potent oncogene in HCC progression. This evidence concerns the gene RPL5 and hepatocellular carcinoma.