Our Western blotting revealed that MID1IP1 depletion attenuated pro-PARP, c-Myc and activated p21 in HepG2 and Huh7 cells, while MID1IP1 overexpression activated c-Myc and reduced p21 in HepG2 cells, demonstrating the pivotal role of MID1IP1 in HCC progression. Here, MYC is linked to hepatocellular carcinoma.