Because many immunotherapies target the mechanisms that restrain T cells to enhance tumor immunity, such as blockade of cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) with ipilimumab [71] or programmed death protein 1 (PD-1) with pembrolizumab [72], these approaches could adversely impact normal cardiac tissue [66,67,71,72]. This evidence concerns the gene CTLA4 and neoplasm.