Similarly, rats that were orally fed DMF (25 mg/kg) prior to and after L-arginine-induced-chronic pancreatitis resulted in improved glucose tolerance, better-preserved tissue architecture (less atrophy, edema, and fatty infiltration) (p < 0.05), significantly lower levels of inflammatory markers (myeloperoxidase (MPO) and MDA), and significantly higher expression of antioxidants (i.e., HO-1) [42]. This evidence concerns the gene MPO and chronic pancreatitis.