CD79A and infection: In contrast to previous studies where IgG bNAbs were artificially converted to IgA for functional analysis (Duchemin et al., 2018, Tudor et al., 2012, Wolbank et al., 2003), these IgA bNAbs were naturally produced in patients during HIV-1 chronic infection, thus making it feasible to assess naturally produced IgA bNAbs for protection and determine whether IgA bNAbs function similarly to or differently from their IgG counterparts at the mucosal portal of infection.