In comparison, the GI50values for a panel of hematologic and solid tumor cell lines that lacked knownalterations in the FGFR genes exceeded 2,500 nM (S3 Table);many of these cell lines are known to have dependencies on other oncogenes (e.g.EGFR, HCC-422; K-Ras, A549, and UMUC3). This evidence concerns the gene KRAS and hepatocellular carcinoma.