HHIP and cancer: Numerous identified genes have been reported to participate in the development of other cancers, for instance, COL11A1, MMP1, COL10A1, HHIP, and COL6A6 could be prognostic and predictive indicators of early-stage non-small cell lung cancer (NSCLC) [50]; upregulation of ITBG3 and COL4A3 genes could respectively promote colorectal cancer and breast cancer development [51, 52].