The pathway analyses for metastasis-associated PAN-ECM genes listed in Table 3 showed that module 1 and 2 possessed the highest proportions (52% and 30% respectively) of PAN-ECM genes, where those PAN-ECM genes are involved in three pathways, GP6 signaling, dendritic cell maturation, and osteoarthritis pathways, suggesting that those PAN-ECM genes and their involved pathways may play crucial roles during EC metastasis. The gene discussed is GP6; the disease is osteoarthritis.