Studies have reported the contributing factors of MYH3 towards distal arthrogryposis type I, 2A (Freeman-Sheldon syndrome) and 2B (Sheldon-Hall syndrome), contractures, pterygia, and variable skeletal fusions syndrome 1A (OMIM 178110) and 1B (OMIM 618469). This evidence concerns the gene MYH3 and Freeman-Sheldon syndrome.