The Cardiovascular Health Study has reported that an increase in the plasma levels of FFA by 200 μmol/L presents an 11% higher risk of AF occurrence even after adjustment for confounding risk factors including age, sex, race, physical activity, body mass index, coronary heart disease, congestive heart failure, smoking, alcohol use, log-C-reactive protein, diabetes mellitus, and hypertension in older adults [6]. The gene discussed is CRP; the disease is atrial fibrillation.