AKT1 and malignant peripheral nerve sheath tumor: GSEA analysis revealed an inhibition of several tumorigenic pathways in MPNST cells by HuR silencing, including the YAP/TAZ, Wnt/β-catenin, PI3K/AKT/mTOR, and RAS pathways, in addition to signatures for the key oncogenic TFs MYC and E2F (Figure 6C and Supplemental Tables 5 and 6).