AKT1 and malignant peripheral nerve sheath tumor: In addition, recent studies have shown that activation of multiple signaling pathways, including the PI3K/AKT/mTOR, RAS/RAF-MEK-ERK, Wnt/β-catenin, and HIPPO-YAP/TAZ pathways, and other less ubiquitous molecular alterations involving aurora kinases and transcription factors (TFs) such as SOX9, also contribute to MPNST pathogenesis (1, 3, 6).