In this study, we show that the RBP HuR has pleiotropic functions in MPNSTs, driving tumor growth and metastasis by, quite strikingly, influencing almost all key signaling pathways and regulators discovered in MPNSTs so far, including the PI3K/AKT/mTOR, RAS/RAF-MEK-ERK, Wnt/β-catenin, and HIPPO-YAP/TAZ pathways, and transcriptional regulators including SOX9, AURKA/B, and BRD proteins, as well as the proto-oncogenic TFs MYC and E2Fs. This evidence concerns the gene SOX9 and neoplasm.