In addition, recent studies have shown that activation of multiple signaling pathways, including the PI3K/AKT/mTOR, RAS/RAF-MEK-ERK, Wnt/β-catenin, and HIPPO-YAP/TAZ pathways, and other less ubiquitous molecular alterations involving aurora kinases and transcription factors (TFs) such as SOX9, also contribute to MPNST pathogenesis (1, 3, 6). Here, MTOR is linked to malignant peripheral nerve sheath tumor.