Mechanistically, our RIP-Chip and transcriptomics data showed a global dysregulation of several signaling pathways and molecular regulators in these cancer cells, including the HIPPO-YAP/TAZ, PI3K/AKT/mTOR, RAS/RAF-MEK-ERK, and Wnt/β-catenin pathways and bromodomain regulation of gene transcription, while our focused analyses revealed that regulation by HuR of specific components of these pathways likely led to the aberrant signaling. Here, AKT1 is linked to cancer.