Recent genome-wide association studies (GWASs) revealed that variants in adducing-3 (ADD3), glypican-1 (GPC1), adenosine diphosphate-ribosylation factor-6 (ARF6) and epidermal growth factor-containing fibulin-like extracellular matrix protein 1 (EFEMP1) were associated with BA susceptibility [9, 10, 12, 16]. The gene discussed is ARF6; the disease is breast angiosarcoma.