Although it is frequently implied that VWF is only important for platelet capture under high shear conditions, murine models of venous thrombosis with no collagen exposure have repeatedly revealed an important role for VWF-mediated platelet accumulation (Bergmeier et al., 2008; Brill et al., 2011; Chauhan et al., 2007). This evidence concerns the gene VWF and Venous thrombosis.