This provides a previously uncharacterized mechanism of how platelet-neutrophil cross-talk is manifest in innate immunity; it also provides an explanation for how VWF and platelet-dependent neutrophil recruitment and NETosis may occur in thrombotic disorders such as DVT (Laridan et al., 2019), but also thrombotic microangiopathies like thrombotic thrombocytopenic purpura (Fuchs et al., 2012b). Here, VWF is linked to thrombotic disease.