Serotonergic neurons in the raphe nucleus projecting to the amygdala are thought to be the neural pathway responsible for suppression of cataplexy by orexin neurons, since activation of serotonergic neurons or activation of serotonergic nerve terminals in the amygdala prevents cataplexy (Hasegawa et al., 2014; Hasegawa et al., 2017). The gene discussed is HCRT; the disease is Cataplexy.