GPT and malaria: Treatment with ibuprofen is more effective than acetaminophen in lowering temperatures in malaria patients throughout the first 4.5 hours after dosing.80 Ibuprofen can be safely administered to healthy participants in a fasted state without increased risk of gastrointestinal toxicity.81 Alanine aminotransferase elevations can occur with ibuprofen doses of 2.4–3.2 g daily, but are generally mild.82 However, potential adverse effects, such as the known association of NSAIDs with acute kidney injury,83 requires specific evaluation in VISs.