Treatment with ibuprofen is more effective than acetaminophen in lowering temperatures in malaria patients throughout the first 4.5 hours after dosing.80 Ibuprofen can be safely administered to healthy participants in a fasted state without increased risk of gastrointestinal toxicity.81 Alanine aminotransferase elevations can occur with ibuprofen doses of 2.4–3.2 g daily, but are generally mild.82 However, potential adverse effects, such as the known association of NSAIDs with acute kidney injury,83 requires specific evaluation in VISs. Here, GPT is linked to acute kidney injury.