HAND2 and neoplasm: As shown in Figure 5E, the protein expression of N‐cadherin, vimentin, MMP‐2 and MMP‐9 was profoundly elevated in tumours of nude mice injected with oe‐HAND2‐AS1 + sh‐E2F4 and oe‐HAND2‐AS1 + oe‐C16orf74 (P < .05).