HAND2‐AS1 restoration resulted in reduced N‐cadherin, vimentin, MMP‐2 and MMP‐9 expression, which was consistent with a former study in which HAND2‐AS1 reduced MMP‐2 and MMP‐9 expressions in chronic myeloid leukaemia.29 Here, VIM is linked to chronic myelogenous leukemia, BCR-ABL1 positive.