CBLN1 and metastatic malignant neoplasm: They claim that the “simple notion of the balance” between Sph-1-phosphate and Cer as dictating cell survival is not in accordance with several recent studies, e.g., that selective Sph kinase 1 inhibitors do not affect cancer cell proliferation or survival, and the fact that several studies demonstrate higher Cer levels in some metastatic cancers.