The effect of 100 μM of the purine cNMPs 3′,5′-cAMP, 3′,5′-cGMP, and 3′,5′-cIMP as well as of the pyrimidine cNMPs 3′,5′-cUMP and 3′,5′-cCMP on αCD3-antibody-induced IL-2 production of HuT-78 lymphoma cells was analyzed by ELISA. This evidence concerns the gene IL2 and lymphoma.