OSCC is the most common form of cancer affecting oral cavity. Researchers have found that salivary levels of specific proteins such as, CD44 (a cell surface glycoprotein involved in cell-to-cell interaction), Cyfra 21-1 (a fragment of cytokeratin 19), tissue polypeptide antigen (TPS), and cancer antigen 125 (CA-125) are increased in patients with OSCC and have been suggested as oral cancer biomarkers [22]. This evidence concerns the gene MUC16 and lip and oral cavity carcinoma.