However, ATM clusters are also seen during acute caloric restriction.22 Thus, they may also play an important role in lipid clearance during weight loss.23 Crownlike structures (CLSs) are formed by macrophages coalesced around dead hypertrophied adipocytes in inflamed adipose tissue, which are mainly seen in the context of obesity, and have been associated with increased insulin resistance.24, 25, 26 This suggests that weight loss should lead to a reduction in inflammatory mediators, macrophages, and CLS. Here, ATM is linked to obesity due to melanocortin 4 receptor deficiency.