TLR4 and infection: TLR4 inhibitors may be particularly helpful in pregnant women at high risk of excessive inflammation as a result of exposures to environmental toxins or stressors, which can elevate TLR4 expression in the absence of infection.138, 139 Other at‐risk women can be identified on the basis of TLR4 gene polymorphisms associated with an increased risk of spontaneous preterm delivery.140, 141