CCN2 and gastric cancer: YAP1 KD decreased its downstream target CTGF, while AMOTL1 KD caused the reduction of YAP1 as well as CTGF in GC cell lines; meanwhile, overexpression of AMOTL1 upregulated both YAP1 and CTGF (Fig. 4h and Supplementary File: Fig. S2b, lower panel).