It is worth noting though that, despite the fact that a number of different ophthalmic conditions has been linked to CACNA1F variants (including iCSNB, Åland eye disease and X-linked cone-rod dystrophy 3), incomplete penetrance is certainly not a frequent feature of CACNA1F-related disorders [52, 55]. Here, CACNA1F is linked to X-linked cone-rod dystrophy 3.