HLA-DRB1 and type 1 diabetes mellitus: For instance, although the DRB1*03:01~DQA1*05:01 g~DQB1*02:01 haplotype was the most frequent in individuals with T1D (28.9%), the haplotype with the largest effect was DRB1*04:01~DQB1*03:01 g~DQA1*03:02 (OR 6.6, CI 4.91–8.87, p-value <0.000001).