TNFAIP8 overexpression is associated with increased tumor metastasis11–13, and TNFAIP8 gene single nucleotide polymorphisms (SNPs) are associated with the development of several inflammatory diseases including inflammatory bowel disease (IBD) with pyoderma gangrenosum14, multiple sclerosis15 and plantar fasciitis16, as revealed from recent genome-wide association studies (GWAS). The gene discussed is TNFAIP8; the disease is inflammatory bowel disease.