To determine the roles of TIPE2 and TNFAIP8 in experimental autoimmune encephalomyelitis (EAE), an animal model for MS, we immunized WT, Tipe2–/–, Tnfaip8–/–, and Tipe2–/–Tnfaip8–/–DKO mice with myelin oligodendrocyte glycoprotein (MOG) peptide 35–55, and monitored daily for clinical signs of EAE (Supplementary Fig. 4a). Here, TIPE2 is linked to experimental autoimmune encephalomyelitis.