Then, we examined the effects of the candidate targets on HCC prognosis using an online database Kaplan Meier-plotter18, which showed that high levels of FGFR4 may be related to poorer overall survival (P = 0.053) and recurrence free survival (P = 0.15)25, while, EGFR had adverse prognostic data (Fig. 4a). The gene discussed is FGFR4; the disease is hepatocellular carcinoma.