These novel findings document a unique regulation of c-Myc oncogene and the survival of ERPC cells by 5-Lox-mediated signaling and suggest that targeting 5-Lox may turn out to be an excellent approach to effectively and selectively eliminate the ERPC cells via induction of apoptosis, which may help establish a new foundation to overcome ERPC and prevent prostate cancer recurrence. Here, MYC is linked to prostate cancer.