Recently, we reported that inhibition of 5-Lox activity down-regulates c-Myc in prostate cancer cells, but not in normal, non-cancer cells, suggesting a selective role of 5-Lox-mediated metabolism of arachidonic acid (a common dietary omega-6 fatty acid) in the regulation of c-Myc in cancer cells17,18. Here, ALOX5 is linked to cancer.