Haplotype analysis of these five NLRP3 SNPs showed that haplotype C-A-A-A-A (NLRP3 rs1539019, NLRP3 rs10925026, NLRP3 rs12143966, NLRP3 rs3806268, and NLRP3 rs12048215) significantly increased the risk of RCC compared to the other haplotypes after multivariate adjustment. Here, NLRP3 is linked to renal cell carcinoma.