NLRP3 and renal cell carcinoma: Subjects with the NLRP3 rs1539019 C allele and total urinary arsenic concentration of ≥ 15.6 μg/g creatinine had a higher OR of RCC (2.33, 1.70–3.19) compared to those with the NLRP3 rs1539019 A allele, whose total urinary arsenic concentration was <15.6 μg/g creatinine after multivariable adjustment (Table 3).