Additionally, the NLRP3 rs1539019 C, NLRP3 rs12239046 C, NLRP3 rs10925025 G, NLRP3 rs10925026 A, and NLRP3 rs10157379 T alleles tended to multiplicatively interact with high total urinary arsenic concentrations on the risk of RCC. The gene discussed is NLRP3; the disease is renal cell carcinoma.