CFTR and cystic fibrosis: In support of this, experiments were performed in either the commonly-used 16HBE bronchial epithelial cell line expressing WT-CFTR or with CFTR transiently knocked down (CF), or the IB3-1 CF cell line (bearing F508del/W1282X genotype) alongside IB3-1 cells virally transduced to express WT-CFTR (C38 cells).