TP53 and cardiac hypertrophy: To determine whether p53 also mediates MEndoT after cardiac hypertrophy, we generated Col1a2-CreERT: R26RtdTomato: p53CKO mice [Col1a2-CreERT: R26RtdTomato: p53fl/fl mice, referred to as conditional knockout] and subjected them to TAC, and fibroblasts with p53 deficiency following tamoxifen administration were also labeled by tdTomato fluorescence.