DNMT1 and Hyperglycemia: Consistent with Mfn2, Dnmt inhibitors also restored hyperglycemia-induced elevation in 5mC at Mlh1 promoter DNA and decrease in its gene transcripts; the values in PC-GC/Aza or PC-GC/D-si or PC/Aza or PC/D-si groups were not different from those in Norm or GC groups (Fig. 5a,b).