Rats receiving Aza or Dnmt1-siRNA, either throughout the eight months of poor glycemia (PC/Aza or PC/D-si groups), or during the four months of good glycemia (PC-GC/Aza, PC-GC/D-si groups), had similar body weight, blood glucose and urine volumes as in PC and PC-GC groups respectively, suggesting that Aza or Dnmt1-siRNA had no effect on the severity of hyperglycemia (Table 1). The gene discussed is DNMT1; the disease is Hyperglycemia.