BRAF and cancer: To evaluate whether such structural disruption is due to a specific cancer-driven molecular pathway or a common feature, we imaged heterochromatin structure in another mouse model of intestinal tumorigenesis—Villin-Cre/BRAFV600E/+ in which the tumor-initiating event in oncogene BRAF (mostly the mutation V600E) occurs in ~20% of colorectal carcinogenesis38.