CD22 and acute lymphoblastic leukemia: More recently, Ramakrishna et al.31 demonstrated that natural bryostatin 1-promoted increases in CD22 surface expression can improve the efficacy and durability of CAR T-mediated tumor clearance in in vivo models of ALL, suggesting that bryostatin and as yet unexplored analogs could be used to improve patient outcomes when used in combination with anti-CD22 CAR T therapy.