T2D α-cells (Fig. 5d) behaved identical to ND α-cells with regard to somatostatin (17 cells/3 donors, blue), insulin (23 cells/3 donors, green) and adrenaline (p = 2 × 10−12, 10 cells/2 donors, pink), except for a moderate reduction of exocytosis at 1 mM glucose. The gene discussed is INS; the disease is type 2 diabetes mellitus.