In conclusion, TGFBI, TNC, and FN1, predicted by our experimental model as migration-promoting proteins secreted by TAMs were validated to be (i) present in the HGSC ascites, (ii) secreted by TAMs derived from ascites, (iii) associated with a poor clinical outcome, and (iv) promote tumor migration as part of the TAM secretome. Here, TGFBI is linked to neoplasm.