IFNG and non-small cell lung carcinoma: In this manuscript, we sought to investigate how IFNγ responsiveness is regulated in a panel of mouse and human NSCLC lines, with a primary focus on the CMT167 and LLC mouse lung tumor lines that differ in their response to PD-1/PD-L1-targeted blockade.11 LLC cells are resistant to checkpoint blockade with PD-1/PD-L1 antibodies16 and have a relatively high basal pERK levels (figure 3); conversely, CMT167 cells are sensitive to checkpoint blockade16 and have low basal pERK levels.